Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant
optrA
-positive
Enterococcus faecalis
sequence type (ST) 16 isolated from a patient with a urinary tract infection (UTI). No travels overseas, contact with food-producing animals or previous treatment with linezolid were reported. Plasmid analysis suggested the chromosomal location of
optrA
gene. Additionally, whole genome sequencing data revealed the association of
optrA
with transposon Tn
554
and the coexistence with
fexA, spc
and
ermA
-like resistance genes. A similar genetic structure has been previously identified in an ST767
E. faecalis
from Taiwan.
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