In a prospective study in AIDS patients with chronic diarrhea, the overall prevalence of intestinal cryptosporidiosis was 15.6% (43/275). The prevalence was higher in homosexual patients (33.3%) than in intravenous drug abusers (10.6%) (p < 0.001). Extraintestinal infection was present in 30% (13/43) of the patients with known intestinal cryptosporidiosis. Eight of the 13 (61.5%) patients with extraintestinal cryptosporidiosis had Cryptosporidium in the bile and 7 of 13 (16.28%) had it in the sputum. Of the seven patients with Cryptosporidium in the sputum, four had respiratory symptoms and an abnormal chest radiograph, although another pulmonary pathogen was isolated simultaneously. Two other patients from whom Cryptosporidium was the sole respiratory pathogen isolated had no respiratory symptoms and normal chest radiographs. The seventh patient had pulmonary symptoms, interstitial infiltrate on chest radiograph and excessive activity on a pulmonary Gallium scan; Cryptosporidium was the only organism detected in induced sputum and bronchoalveolar lavage specimens. The mean CD4+ lymphocyte count in patients with extraintestinal cryptosporidiosis was 55 cells/mm3.
We call projectile fragmentation of neutron halo nuclei the elastic breakup (diffraction) reaction, when the observable studied is the neutron-core relative energy spectrum. This observable has been measured in relation to the Coulomb breakup on heavy target and recently also on light targets. Such data enlighten the effect of the neutron final state interaction with the core of origin. Projectile fragmentation is studied here by a time dependent model for the excitation of a nucleon from a bound state to a continuum resonant state in a neutron-core complex potential which acts as a final state interaction. The final state is described by an optical model S-matrix so that both resonant and non resonant states of any continuum energy can be studied as well as deeply bound initial states. It turns out that due to the coupling between the initial and final states, the neutron-core free particle phase shifts are modified, in the exit channel, by an additional phase. Some typical numerical calculations for the relevant observables are presented and compared to experimental data. It is suggest that the excitation energy spectra of an unbound nucleus might reflect the structure of the parent nucleus from whose fragmentation they are obtained.
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