These results suggest that a functioning nitric oxide system, especially through the nNOS, is important in mediating normal renal responses and that increased production of and/or sensitivity to nitric oxide during sustained VE plays an important role in the adaptive mechanism of the tubuloglomerular feedback.

TEB(Aesculon) overestimated CO compared to TD with ∼17% at rest and ∼34% during exercise, but the techniques showed similar results during NO inhalation. CO, furthermore, correlated poorly between TEB(Aesculon) and TD. TEB(Aesculon) may at present not replace TD for reliable CO measurements in humans.

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