The scenario of the formation of light bullets in the presence of anomalous group velocity dispersion is presented within the same general scenario for condensed matter and humid air. The temporal and spectral parameters of light bullets during filamentation in fused silica and humid air are obtained. A light bullet (LB) is a short-lived formation in a femtosecond filament with a high spatiotemporal light field localization. The sequence formation of the quasi-periodical LB is obtained numerically and is confirmed experimentally by autocorrelation measurements of the LB’s duration. The estimation of the LB duration reaches few-cycle value. It is established that the generation of each LB is accompanied by the ejection of a supercontinuum (SC) in the visible spectrum and an isolated anti-Stokes wing is formed in the visible area of the SC as a result of destructive interference of broadband spectral components. It was found that the energy of a visible SC increases discretely according to the number of LBs in the filament. We demonstrated that the model of ionization in solid dielectric which is used in numerical simulation fundamentally affects the obtained scenario of LB formation. The possibility of the formation of LBs under the filamentation of middle-IR pulses in the atmosphere was shown with numerical simulation.
Outer-membrane proteases T (OmpT) are membrane enzymes used for defense by Gram-negative bacteria. Here we use hybrid molecular mechanics/coarsegrained simulations to investigate the role of large-scale motions of OmpT from Escherichia coli for its function. In this approach, the enzyme active site is treated at the all-atom level, whilst the rest of the protein is described at the coarse-grained level. Our calculations agree well with previously reported all-atom molecular dynamics simulations, suggesting that this approach is well suitable to investigate membrane proteins. In addition, our findings suggest that OmpT large-scale conformational fluctuations might play a role for its biological function, as found for another protease class, the aspartyl proteases.
Paper concerns experimental and numerical investigation on supercontinuum emission in the process of femtosecond beam filamentation under different geometrical focusing in presence of anomalous group velocity dispersion in fused silica. It was shown that energy of supercontinuum visible part increases discretely with increasing of input laser pulse energy. It is connected with light bullets formation. Also it was found that energy of supercontinuum visible part connected with each bullet doesn't depend on focusing geometry.
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