The aim of this study was to examine the effects of vitamin C on malonaldehyde (MDA) and glutathione (GSH) concentrations, and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in chickens stressed by adrenocorticotropin (ACTH). Sixty Leghorn chickens (20 weeks old) were randomly allotted to a control and a vitamin C treated group. An isotonic sodium chloride solution was administrated intramuscularly for a period of five days to the control group at a dose of 2.5 mL per chicken per day, and the treatment group received a vitamin C solution (containing 250 mg vitamin C/2.5 mL) intramuscularly for five days. On the fifth day of the experiment the chickens in both groups received 50 IU ACTH intramuscularly. Three hours after ACTH application blood samples were collected to determine the concentrations of MDA and GSH, and activities of SOD and GSH-Px in the blood. The concentration of MDA in the control group increased compared to that in the vitamin C treated group. After the ACTH application the activity of SOD increased in both groups, thought significantly so in the vitamin C treated group. The GSH-Px activity did not differ significantly between the treatments after ACTH application. It was concluded that intramuscularly administrated vitamin C facilitated an adaptation against stress and decreased negative effects of stress in chickens.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.