Origin and genetic differentiation of three Native Mexican groups (Purépechas, Triquis and Mayas): Contribution of CODIS-STRs to the history of human populations of Mesoamerica

Martínez-Cortés, Gabriela; Nuño‐Arana, Ismael; Rubí-Castellanos, Rodrigo; Vilchis-Dorantes, G.; Luna-Vázquez, A.; Coral‐Vázquez, Ramón Mauricio; Canto-Cetina, Thelma; Salazar-Flores, Joel; Muñoz-Valle, J.F.; Sandoval-Mendoza, Karla; López, Zaira; Gamero-Lucas, J. J.; Rangel-Villalobos, Héctor

doi:10.3109/03014461003743801

Cited by 31 publications

(17 citation statements)

References 40 publications

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“…STRs are most commonly used in forensics (Butler, 2005); however, these widely distributed and highly mutable elements are also excellent markers for establishing genetic structure, diversity and genetic differentiation within human populations (Sun et al, 2013b). In fact, STR analysis can be used to reconstruct recent human history and assess the phylogenetic relationships between populations on a global level (Martinez-Cortes et al, 2010;Sun et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis

Martínez-González¹,

Álvarez-Cubero

Saiz

et al. 2015

Annals of Human Biology

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The Mayan populations from Guatemala and other Native American groups display high genetic homogeneity. Genetic relationships between these groups are more affected by cultural and linguistic factors than geographical and local flow. This study represents one of the first steps in understanding Mayan-Guatemalan populations, the associations between their sub-populations and differences in gene diversity with other populations. This article also demonstrates that the Mestizo population shares most of its ancestral genetic components with the Guatemala Mayan populations.

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Section: Introductionmentioning

confidence: 99%

Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis

Martínez-González¹,

Álvarez-Cubero

Saiz

et al. 2015

Annals of Human Biology

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“…Mexican Amerindians constitute > 68 Native groups, > 85 languages and variant dialects, and are geographically located mainly in the Center and Southeast of the country (Martinez-Cortes et al, 2010). Conversely, MexicanMestizos are widely distributed throughout the country, comprise *93% of the total population, and arose during and after European contact with the New World by admixture among Spaniards, Amerindians, and, to a lesser degree, with African slaves (Rubi-Castellanos et al, 2009).…”

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confidence: 99%

Distribution of CYP2D6 and CYP2C19 Polymorphisms Associated with Poor Metabolizer Phenotype in Five Amerindian Groups and Western Mestizos from Mexico

Salazar-Flores

Torres-Reyes

Martínez-Cortés

et al. 2012

Genetic Testing and Molecular Biomarkers

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Background: The distribution of polymorphisms in the CYP2D6 and CYP2C19 genes allows inferring the potential risk for specific adverse drug reactions and lack of therapeutic effects in humans. This variability shows differences among human populations. The aim of this study was to analyze single-nucleotide polymorphisms related to a poor metabolizer (PM) phenotype in nonpreviously studied Amerindian groups and Mestizos (general admixed population) from Mexico. Methods: We detected by SNaPshot Ò different polymorphisms located in CYP2D6 (*3, *4, *6, *7, and *8) and CYP2C19 (*2, *3, *4 and *5) in western Mestizos (n = 145) and five Amerindian groups from Mexico: Tarahumaras from the North (n = 88); Purépechas from the Center (n = 101); and Tojolabales (n = 68), Tzotziles (n = 88), and Tzeltales (n = 20) from the Southeast. Genotypes were observed by capillary electrophoresis. The genetic relationships among these populations were estimated based on these genes. Results and Discussion: The wild-type allele (*1) of both genes was predominant in the Mexican populations studied. The most widely observed alleles were CYP2C19*2 (range, 0%-31%) and CYP2D6*4 (range, 1.2%-7

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“…markers from a forensic perspective; particularly the Southern region characterized by the presence of numerous Mexican indigenous communities, which could potentially increase the Amerindian ancestry of the neighboring southern Mestizo populations. 4 Therefore, the two defined objectives of this study were:…”

Section: Introductionmentioning

confidence: 99%

Statistical Parameters of Forensic Importance for 15 Autosomal STRs in Mestizo Population from the State of Guerrero (South Mexico)

Locia-Aguilar¹,

López-Saucedo²,

Deheza-Bautista³

et al. 2017

Toxicol Forensic Med Open J

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Origin and genetic differentiation of three Native Mexican groups (Purépechas, Triquis and Mayas): Contribution of CODIS-STRs to the history of human populations of Mesoamerica

Cited by 31 publications

References 40 publications

Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis

Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis

Distribution of CYP2D6 and CYP2C19 Polymorphisms Associated with Poor Metabolizer Phenotype in Five Amerindian Groups and Western Mestizos from Mexico

Statistical Parameters of Forensic Importance for 15 Autosomal STRs in Mestizo Population from the State of Guerrero (South Mexico)

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