Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans

Kondo, Narihiko; Tominaga, Hiroo; Shibasaki, Manabu; Aoki, Ken; Koga, Shunsaku; Nishiyasu, Takeshi

doi:10.1111/j.1469-7793.1999.591ac.x

Cited by 61 publications

(105 citation statements)

References 27 publications

(61 reference statements)

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“…Conversely, PEMI is a well-established method for evaluating the effects of muscle metaboreceptor activation on the sweating response, as evidenced by the significant increases in SR and blood pressure during PEMI (2, 4, 7, 22). Although it has been reported that cuff inflation itself can stimulate muscle mechanoreceptors (29, 44), we reported previously that forearm occlusion (240 mmHg) for 2 min without prior isometric handgrip exercise under hot conditions did not evoke any changes in HR, MAP, or SR (22). This suggests that forearm cuff inflation itself during PEMI did not affect the physiological responses observed in the present study.…”

Section: Discussionsupporting

confidence: 37%

“…It is well known that group III muscle afferents are stimulated predominantly by mechanically sensitive muscle mechanoreceptors, whereas group IV muscle afferents are stimulated mainly by chemically sensitive muscle metaboreceptors. Activation of muscle metaboreceptors by postexercise muscle ischemia (PEMI) under normothermic and mildly hot conditions induces sweating (2,4,22,38). Additionally, Kondo et al (23) reported that activating the muscle mechanoreceptors by passive limb movement for 2 min evoked slight sweating under hot conditions.…”

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confidence: 99%

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Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Amano

Ichinose

Nishiyasu

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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-Activation of muscle metaboreceptors and mechanoreceptors has been shown to independently influence the sweating response, while their integrative control effects remain unclear. We examined the sweating response when the two muscle receptors are concurrently activated in different limbs, as well as the blood pressure response. In total, 27 young males performed passive calf muscle stretches (muscle mechanoreceptor activation) for 30 s in a semisupine position with and without postisometric handgrip exercise muscle ischemia (PEMI, muscle metaboreceptor activation) at exercise intensities of 35 and 50% of maximum voluntary contraction (MVC) under hot conditions (ambient temperature, 35°C, relative humidity, 50%). Passive calf muscle stretching alone increased the mean sweating rate significantly on the forehead, chest, and thigh (SRmean) and mean arterial blood pressure (MAP), but not the heart rate (HR), from prestretching levels by 0.04 Ϯ 0.01 mg·cm 2 ·min Ϫ1 , 4.0 Ϯ 1.3 mmHg (P Ͻ 0.05), and Ϫ1.0 Ϯ 0.5 beats/min (P Ͼ 0.05), respectively. The SRmean and MAP during PEMI were significantly higher than those at rest. The passive calf muscle stretch during PEMI increased MAP significantly by 3.4 Ϯ 1.0 and 2.0 Ϯ 0.7 mmHg for 35 and 50% of MVC, respectively (P Ͻ 0.05), but not that of SRmean or HR at either exercise intensity. These results suggest that sweating and blood pressure responses to concurrent activation of the two muscle receptors in different limbs differ and that the influence of calf muscle mechanoreceptor activation alone on the sweating response disappears during forearm muscle metaboreceptor activation. nonthermal factors; group III and IV muscle afferents; thermoregulation; sympathetic nervous system; sweat gland THE SWEATING RESPONSE DURING exercise is controlled not only by core and skin temperatures (thermal factors) but also by exercise-related (nonthermal) factors, such as afferent inputs from working muscles. It is well known that group III muscle afferents are stimulated predominantly by mechanically sensitive muscle mechanoreceptors, whereas group IV muscle afferents are stimulated mainly by chemically sensitive muscle metaboreceptors. Activation of muscle metaboreceptors by postexercise muscle ischemia (PEMI) under normothermic and mildly hot conditions induces sweating (2, 4, 22, 38). Additionally, Kondo et al. (23) reported that activating the muscle mechanoreceptors by passive limb movement for 2 min evoked slight sweating under hot conditions. Furthermore, the muscle mechanoreflex increases the sweating response during passive recovery (passive limb movement using a tandem ergometer) compared with inactive recovery (resting) after cycling (20,39). These studies suggest that the isolated activation of muscle metaboreceptors and mechanoreceptors can independently affect sweating responses. However, the sweating response is presumably controlled by integrative mechanisms, based on afferent signals from muscle metaboreceptors and mechanoreceptors because physiological integrative control h...

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Section: Discussionsupporting

confidence: 37%

mentioning

confidence: 99%

Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Amano

Ichinose

Nishiyasu

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…These changes are significant given that the lactate turnpoint (LTP) remains a strong predictor of time trial performance in hot environments (Lorenzo et al 2011) and appears sensitive to the effects of IP (Bailey, Jones, et al 2012), whilst V" O 2max is considered the best individual predictor of performance, explaining 90.2% of the total variance in a 16-km run (McLaughlin et al 2010). Furthermore, evidence exists that occlusion may modify thermoregulatory responses, through the muscle metaboreflex, independently of body temperature (Kondo et al 1999 (James et al 2015;Randall et al 2015) and heat acclimation (Gibson et al 2015;Mee et al 2015;Willmott et al 2016), that seek to alleviate the significant impairment to endurance performance afforded by heat stress (Guy et al 2015).…”

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confidence: 99%

Ischaemic preconditioning does not alter the determinants of endurance running performance in the heat

et al. 2016

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“…These physiological responses associated with the IHG are related to mechanisms involving central command such as stimulation from the parallel activation of motor and autonomic pathways and the activation of mechanosensitive or metabosensitive receptors in exercising muscle [Crandall et al, , 1998Kondo et al, 1998Kondo et al, ,1999Rowell & O'Leary, 1990].…”

Section: Effect Of Exercise Intensity On the Ihg-mediated Response Ofmentioning

confidence: 99%

“…In the palmar skin, it is well known that the sweating rate can increase without changes in the internal temperature [Kondo et al, , 1999Van Beaumont & Bullard, 1963, 1966. The changes in the sweating rate may be due to non-thermal factors involving activation of mechanosensitive or metabosensitive receptors in exercising muscles Van Beaumont & Bullard, 1963] or emotional or mental stimulation [Kuno, 1956].…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise intensity, posture, pressure on the back and ambient temperature on palmar sweating responses due to handgrip exercises in humans

Tomioka

Kobayashi

Ushiyama

et al. 2005

Autonomic Neuroscience

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We have, by using newly developed ratemeters, attempted to examine the effects of exercise intensity, posture, pressure on the skin of the back, and ambient hyperthermic conditions (~30 °C) on the 5-s handgrip exercise-mediated responses of active palmar sweating in humans.Thirty-five right-handed male (n=5) and female (n=30) important that subjects maintain a constant handgrip force and posture and that ambient temperature be kept under normothermic conditions. 4

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Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans

Cited by 61 publications

References 27 publications

Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Ischaemic preconditioning does not alter the determinants of endurance running performance in the heat

Effects of exercise intensity, posture, pressure on the back and ambient temperature on palmar sweating responses due to handgrip exercises in humans

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