Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study

Morris, Ciara; O'Grada, Colm; Ryan, Mary Morgan; Gibney, Michael J.; Roche, Helen M.; Gibney, Eileen R.; Brennan, Lorraine

doi:10.1186/s12944-015-0062-x

Cited by 21 publications

(21 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, nine phospholipids, mostly phosphatidylethanolamines, were shown to be related to food intake in mixed model repeated measures analyses. In a previous oral lipid challenge in humans, phosphatidylethanolamines (PEaa C36:2 and PCaa C36:3) showed an almost two-fold increase at two hours postprandially [64]. Interestingly, the present dog cohort displayed a comparable increase in the same phospholipids in response to the high-fat feed-challenge test.…”

Section: Discussionsupporting

confidence: 48%

Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs

et al. 2019

View full text Add to dashboard Cite

BackgroundObesity in dogs is an increasing problem associated with morbidity, shortened life span and poor life quality. Overweight dogs exhibit postprandial hyperlipidaemia, highlighting the need to identify potential dysregulations in lipid metabolism. This study investigated metabolites related to lipid metabolism (i.e. acylcarnitines and taurine) and phospholipids in a feed-challenge test and aimed to identify metabolic variations in spontaneously overweight dogs. Twenty-eight healthy male Labrador Retriever dogs were included, 12 of which were classified as lean (body condition score (BCS) 4–5 on a 9-point scale) and 16 as overweight (BCS 6–8). After overnight fasting (14–17 h), fasting blood samples were collected and dogs were fed a high-fat meal followed by postprandial blood sample collection hourly for 4 h. Liquid chromatography-time of flight mass spectrometry (LC-TOFMS) was used to identify plasma metabolites and phospholipids. Multivariate models, mixed model repeated measures and linear regression analyses were used for data interpretation.ResultsIn all dogs, propionylcarnitine, stearoylcarnitine and nine phospholipids increased in response to food intake, while vaccenylcarnitine decreased (P ≤ 0.005 for all). Overall, carnitine and acetylcarnitine signal areas in the feed-challenge test were lower in overweight dogs (P ≤ 0.004). Notably, fasting plasma acetylcarnitine was lower in overweight dogs than in lean dogs (P = 0.001) and it did not change in response to feeding. The latter finding was in contrast to the decreased acetylcarnitine signal area found in lean dogs at one hour postprandially (P < 0.0001). One fasting phosphatidylcholine (PCaa C38:4) was higher in prominently overweight dogs (BCS > 6) than in lean dogs (P < 0.05).ConclusionsPlasma carnitine status was overall lower in spontaneously overweight dogs than in lean dogs in this cohort of healthy Labrador Retriever dogs, indicating a potential carnitine insufficiency in the overweight group. The acetylcarnitine response in overweight dogs indicated decreased fatty acid oxidation at fasting and metabolic inflexibility to food intake. Further studies on metabolic inflexibility and its potential role in the metabolism of overweight dogs are warranted.Electronic supplementary materialThe online version of this article (10.1186/s12917-019-1845-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 48%

Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The effects of exercise on blood lipid levels in elderly people have been widely studied 28 because, with aging, the blood lipid composition undergoes significant changes associated with changes in body composition or the onset of diseases associated with old age. In this study, we observed a significant decrease in the levels of TC, LDL-c, TC/HDL-c, and LDL-C/HDL-c and a significant increase in HDL-c levels in 3 training models.…”

Section: Discussionmentioning

confidence: 99%

Improvement in muscular strength and aerobic capacities in elderly people occurs independently of physical training type or exercise model

Sbardelotto¹,

Costa²,

Malysz³

et al. 2019

Clinics

View full text Add to dashboard Cite

OBJECTIVES: Progressive decline of physiological processes with aging is normal. Aging is also associated with decreased functional capacity and onset of many diseases. This study evaluated the changes in physical fitness (PF), body composition (BC), and lipid profile (LP) in elderly men completing different training protocols. METHODS: Fifty-five men (age 60-80 years) were randomized into the following groups: without training, aerobic training on dry land, combined training on dry land, and combined training in water. Training was conducted for 8 weeks, and PF, LP, and BC were assessed at the beginning and end of the intervention. RESULTS: Significant improvements were observed in all parameters; however, combined programs on land or in water were more effective at improving strength and aerobic fitness. Combined exercise produced greater effects on BC and LP and some muscle fitness parameters; however, improvements in muscular and aerobic capacities occurred independently of exercise type or model. CONCLUSION: These results indicate that the effects of training occur regardless of training type or model, and are directly associated with training periodization, adherence, and regularity.

show abstract

“…This additionally meant that all of the AT donors were both fasting and resting—a requirement that was also matched by the normal blood donors. This is important because human blood (plasma) lipid profiles can be influenced by diet and exercise [35,36]. Third, there are several considerations specific to the surgical procedure itself.…”

Section: Discussionmentioning

confidence: 99%

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema

et al. 2016

View full text Add to dashboard Cite

Cancer-related and primary lymphedema (LE) are associated with the production of adipose tissue (AT). Nothing is known, however, about the lipid-based molecules that comprise LE AT. We therefore analyzed lipid molecules in lipoaspirates and serum obtained from LE patients, and compared them to lipoaspirates from cosmetic surgery patients and healthy control cohort serum. LE patient serum analysis demonstrated that triglycerides, HDL- and LDL-cholesterol and lipid transport molecules remained within the normal range, with no alterations in individual fatty acids. The lipidomic analysis also identified 275 lipid-based molecules, including triacylglycerides, diacylglycerides, fatty acids and phospholipids in AT oil and fat. Although the majority of lipid molecules were present in a similar abundance in LE and non-LE samples, there were several small changes: increased C20:5-containing triacylglycerides, reduced C10:0 caprinic and C24:1 nervonic acids. LE AT oil also contained a signature of increased cyclopropane-type fatty acids and inflammatory mediators arachidonic acid and ceramides. Interestingly C20:5 and C22:6 omega-3-type lipids are increased in LE AT, correlating with LE years. Hence, LE AT has a normal lipid profile containing a signature of inflammation and omega-3-lipids. It remains unclear, however, whether these differences reflect a small-scale global metabolic disturbance or effects within localised inflammatory foci.

show abstract

Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study

Cited by 21 publications

References 54 publications

Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs

Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs

Improvement in muscular strength and aerobic capacities in elderly people occurs independently of physical training type or exercise model

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema

Contact Info

Product

Resources

About