Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans

Ichinose, Masashi; Saito, Mitsuru; Wada, Hiroyuki; Kitano, Asami; Kondo, Narihiko; Nishiyasu, Takeshi

doi:10.1113/jphysiol.2002.024794

Cited by 48 publications

(78 citation statements)

References 42 publications

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“…The unchanged baroreflex regulation of HR during PEMI in this study is consistent with previous reports (7,8,20). Because the HR responses to neck chamber stimuli are predominantly mediated by the CBR control of cardiac parasympathetic activity (5), our results suggest that the interaction between the muscle metaboreflex and the arterial baroreflex does not affect the CBR-mediated regulation of cardiac parasympathetic tone.…”

Section: Discussionsupporting

confidence: 82%

“…Moreover, according to recent findings by Ogoh et al (18), the peak MAP response (normally observed at 6 -8 s after the start of a 5-s neck chamber stimulus) is mainly due to reflex changes in total vascular conductance, with little contribution being made by any change in cardiac output. Previously, we found that during the PEMI-induced activation of the muscle metaboreflex (using the same protocol as that used here), both the MSNA and MAP responses to NP were augmented (7). In the present study, we directly demonstrated that an augmentation of the LVC response to carotid compression occurred during PEMI.…”

Section: Discussionsupporting

confidence: 62%

“…At 9 -10 s, MAP was above baseline, whereas LVC was significantly below baseline at 10 s, indicating vasoconstriction. In a previous study, we (7) found that during PEMI (compared with control), the period of MSNA depression induced by NS was shortened (NS suppressed MSNA only for the first 1 s) and that subsequently MSNA was rapidly augmented despite the continuation of NS. Taken together, the above evidence suggests that during PEMI, the shortening of the suppression of SNA induced by carotid stretch would diminish the CBR vasodilator response while the subsequent rapid augmentation of SNA would cause vasoconstriction (as was indeed observed as the last part of the LVC response).…”

Section: Discussionmentioning

confidence: 99%

“…The assessment of CBR dynamic responses has been described in detail elsewhere (7). Briefly, the 13-s records of MAP, HR, LBF, and LVC obtained during four trials of NP or NS were averaged and integrated over 1-s periods to allow us to assess the time course of the CBR responses.…”

Section: Subjectsmentioning

confidence: 99%

“…Very recently, Ichinose et al (6) reported that the modification of the arterial baroreflex control of MSNA that is seen during PEMI could be a consequence of a muscle metaboreflex-induced alteration in the baroreflex control of both the occurrence and strength of MSNA bursts. Furthermore, a previous study by our laboratory (7) showed that during PEMI (in comparison with the supine rest situation) 1) both the MSNA and mean arterial blood pressure (MAP) responses to NP were augmented, and 2) the period of MSNA depression induced by NS was shortened, and the decrease in MAP was smaller and shorter lasting. From these previous results, we thought that the CBR regulation of peripheral vascular conductance might be modulated by the muscle metaboreflex.…”

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confidence: 99%

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Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans

Ichinose¹,

Nishiyasu²

2005

American Journal of Physiology-Heart and Circulatory Physiology

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by the ultrasound Doppler method), leg vascular conductance (LVC), mean arterial blood pressure (MAP), and heart rate (HR)] in humans. In 12 healthy subjects (10 men and 2 women), who performed sustained 1-min handgrip exercise at 50% maximal voluntary contraction followed immediately by an imposed postexercise muscle ischemia (PEMI), 5-s periods of neck pressure (NP; 50 mmHg) or neck suction (NS; Ϫ60 mmHg) were used to evaluate carotid baroreflex function both at rest (Con) and during PEMI. First, the decreases in LVC and LBF and the augmentation of MAP elicited by NP were all greater during PEMI than in Con (⌬LVC, Ϫ1.2 Ϯ 0.2 vs. Ϫ1.9 Ϯ 0.2 ml ⅐ min Ϫ1 ⅐ mmHg Ϫ1 ; ⌬LBF, Ϫ97.3 Ϯ 11.2 vs. Ϫ177.0 Ϯ 21.8 ml/min; ⌬MAP, 6.7 Ϯ 1.2 vs. 11.5 Ϯ 1.4 mmHg, Con vs. PEMI; each P Ͻ 0.05). Second, in Con, NS significantly increased both LVC and LBF (⌬LVC, 0.9 Ϯ 0.2 ml ⅐ min Ϫ1 ⅐ mmHg Ϫ1 ; ⌬LBF, 46.6 Ϯ 9.8 ml/min; significant change from baseline: each P Ͻ 0.05), and, whereas during PEMI no significant increases in LVC and LBF occurred during NS itself (⌬LVC, 0.2 Ϯ 0.1 ml ⅐ min Ϫ1 ⅐ mmHg Ϫ1 ; ⌬LBF, 10.8 Ϯ 9.6 ml/min; each P Ͼ 0.05), a decrease was evident in each parameters at 5 s after the cessation of NS. Third, during PEMI, the decrease in MAP elicited by NS was smaller (⌬MAP, Ϫ8.4 Ϯ 1.0 vs. Ϫ5.8 Ϯ 0.4 mmHg, Con vs. PEMI; P Ͻ 0.05), and it recovered to its initial level more quickly after NS (vs. Con). Finally, however, the HR responses to NS and NP were not different between PEMI and Con. These results suggest that during muscle metaboreflex activation in humans, the arterial baroreflex dynamic effect on peripheral vascular conductance is modulated, as exemplified by 1) an augmentation of the NP-induced LVC decrease, and 2) a loss of the NS-induced LVC increase. skeletal muscle metaboreflex; carotid baroreflex; exercise DURING HEAVY EXERCISE, the arterial baroreflexes and the reflexes evoked by activation of those afferent nerve endings in the working skeletal muscles that are sensitive to metabolic changes (the so-called muscle metaboreflex) are hypothesized to be activated and, moreover, to interact in ways that lead to modulation of the primary cardiovascular reflex responses (6 -9, 15, 19, 20, 24, 25, 29, 31). Two types of interaction between these reflexes have been demonstrated to lead to such modulation. In the first type, the arterial baroreflexes act to oppose the pressor response elicited via the muscle metaboreflex (15,19,29,31). Evidence for this effect has been obtained during dynamic exercise in dogs (31) as well as during static handgrip exercise (29) and postexercise muscle ischemia (PEMI) in humans (15). The second type of interaction involves a modulation of arterial baroreflex function during muscle metaboreflex activation (6 -9, 20). However, these interactions (especially the second: viz. modulation of arterial baroreflex function by the muscle metaboreflex) and their consequences are not fully understood.Papelier et al. (20) found that during PEMI-induced muscle metaboreflex activation, the carotid sin...

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 99%

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Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans

Ichinose¹,

Nishiyasu²

2005

American Journal of Physiology-Heart and Circulatory Physiology

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Sympathetic Neural Activity to the Cardiovascular System: Integrator of Systemic Physiology and Interindividual Characteristics

Charkoudian

Wallin

2014

Comprehensive Physiology

116

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The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascular function with a focus on integrative mechanisms in humans. Direct measurement of sympathetic neural activity (SNA) in humans can be accomplished using microneurography, most commonly performed in the peroneal (fibular) nerve. In humans, muscle SNA (MSNA) is composed of vasoconstrictor fibers; its best-recognized characteristic is its participation in transient, moment-to-moment control of arterial blood pressure via the arterial baroreflex. This property of MSNA contributes to its typical "bursting" pattern which is strongly linked to the cardiac cycle. Recent evidence suggests that sympathetic neural mechanisms and the baroreflex have important roles in the long term control of blood pressure as well. One of the striking characteristics of MSNA is its large interindividual variability. However, in young, normotensive humans, higher MSNA is not linked to higher blood pressure due to balancing influences of other cardiovascular variables. In men, an inverse relationship between MSNA and cardiac output is a major factor in this balance, whereas in women, beta-adrenergic vasodilation offsets the vasoconstrictor/pressor effects of higher MSNA. As people get older (and in people with hypertension) higher MSNA is more likely to be linked to higher blood pressure. Skin SNA (SSNA) can also be measured in humans, although interpretation of SSNA signals is complicated by multiple types of neurons involved (vasoconstrictor, vasodilator, sudomotor and pilomotor). In addition to blood pressure regulation, the sympathetic nervous system contributes to cardiovascular regulation during numerous other reflexes, including those involved in exercise, thermoregulation, chemoreflex regulation, and responses to mental stress.

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Sympathetic neural control of integrated cardiovascular function: Insights from measurement of human sympathetic nerve activity

2007

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Sympathetic neural control of cardiovascular function is essential for normal regulation of blood pressure and tissue perfusion. In the present review we discuss sympathetic neural mechanisms in human cardiovascular physiology and pathophysiology, with a focus on evidence from direct recordings of sympathetic nerve activity using microneurography. Measurements of sympathetic nerve activity to skeletal muscle have provided extensive information regarding reflex control of blood pressure and blood flow in conditions ranging from rest to postural changes, exercise, and mental stress in populations ranging from healthy controls to patients with hypertension and heart failure. Measurements of skin sympathetic nerve activity have also provided important insights into neural control, but are often more difficult to interpret since the activity contains several types of nerve impulses with different functions. Although most studies have focused on group mean differences, we provide evidence that individual variability in sympathetic nerve activity is important to the ultimate understanding of these integrated physiological mechanisms.

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Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans

Cited by 48 publications

References 42 publications

Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans

Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans

Sympathetic Neural Activity to the Cardiovascular System: Integrator of Systemic Physiology and Interindividual Characteristics

Sympathetic neural control of integrated cardiovascular function: Insights from measurement of human sympathetic nerve activity

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