Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

Hou, Dan; Feng, Jiashi; Li, Jiaoyan; Lian, Jie; Li, Mingyang; Liu, Xinna; Xu, Yanan; Zhang, Chaoyu; Chen, Zhao; Jia, Shuwei; Jiao, Runsheng; Liu, Xiaoyu; Wang, Xiaoran; Zhang, Ying; Wang, Yufeng

doi:10.4172/2167-0501.1000211

Cited by 30 publications

(46 citation statements)

References 147 publications

(144 reference statements)

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“…Oxytocin neurons can integrate information from presynaptic neurons, detect the state of astrocytic plasticity and microglial activation, sense concentrations of blood-borne substances and local neurochemical including cytokines (3, 66–68), and in turn secrete appropriate amount of OT into the blood and brain. This could preset the immune system in an optimal working condition through regulating the activity of bone marrow, thymus, and T-/B-cells as well as other immune organs and tissues (3).…”

Section: Characteristics Of the Oss–immune Networkmentioning

confidence: 99%

“…The VP-secreting system (VSS) and OSS coexist in the HNS (68), and thus, the VSS could also be involved in the immune effects of rat neurointermediate lobectomy (12, 13). In fact, the VSS does have certain immune functions that are often opposite to the OSS (68).…”

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

“…In fact, the VSS does have certain immune functions that are often opposite to the OSS (68). For example, in rat tissue culture, VP inhibits and OT facilitates the growth of thymus gland (98).…”

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

“…For example, the distribution of OTRs in the immune system is more extensive than that of VP receptors as seen in rats (99) and in mice (21). In contrast to the extensive immune functions of the OSS (Table 1), blocking VP signaling can only block the production of interferon-γ by mouse spleen lymphocytes specifically and reversibly (100) along with a few of other functions (68). …”

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

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Approaches Mediating Oxytocin Regulation of the Immune System

Wang

et al. 2017

Front. Immunol.

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The hypothalamic neuroendocrine system is mainly composed of the neural structures regulating hormone secretion from the pituitary gland and has been considered as the higher regulatory center of the immune system. Recently, the hypothalamo-neurohypophysial system (HNS) emerged as an important component of neuroendocrine–immune network, wherein the oxytocin (OT)-secreting system (OSS) plays an essential role. The OSS, consisting of OT neurons in the supraoptic nucleus, paraventricular nucleus, their several accessory nuclei and associated structures, can integrate neural, endocrine, metabolic, and immune information and plays a pivotal role in the development and functions of the immune system. The OSS can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis. Correspondingly, OT can inhibit inflammation, exert antibiotic-like effect, promote wound healing and regeneration, and suppress stress-associated immune disorders. In this process, the OSS can release OT to act on immune system directly by activating OT receptors or through modulating activities of other hypothalamic–pituitary–immune axes and autonomic nervous system indirectly. However, our understandings of the role of the OSS in neuroendocrine regulation of immune system are largely incomplete, particularly its relationship with other hypothalamic–pituitary–immune axes and the vasopressin-secreting system that coexists with the OSS in the HNS. In addition, it remains unclear about the relationship between the OSS and peripherally produced OT in immune regulation, particularly intrathymic OT that is known to elicit central immunological self-tolerance of T-cells to hypophysial hormones. In this work, we provide a brief review of current knowledge of the features of OSS regulation of the immune system and of potential approaches that mediate OSS coordination of the activities of entire neuroendocrine–immune network.

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Section: Characteristics Of the Oss–immune Networkmentioning

confidence: 99%

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

Section: Relationship Between the Oss And Other Neuroendocrine Regulamentioning

confidence: 99%

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Approaches Mediating Oxytocin Regulation of the Immune System

Wang

et al. 2017

Front. Immunol.

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“…For instance, β-alanine release from astrocytes (Pasantes-Morales et al, 1994) can inhibit astrocyte GABA transporters and thus inhibits VP secretion through increasing extracellular GABA (Wang et al, 2013a); coordinated D-serine metabolism between astrocytes and magnocellular neurons along with exhaustion of β-alanine and taurine in the SON can increase NMDA receptor activation, and participate in the recovery of VP neurons from hyposmotic inhibition (Wang et al, 2013b). Thus, astrocytes are important osmosensory cells not only by co-expression of TRPV channels and AQP4 (Benfenati et al, 2011; Mola et al, 2016; Iuso and Križaj, 2016) but also by astrocytic plasticity-associated neuronal effects (Hou et al, 2016; Jia et al, 2016). …”

Section: Cellular Volumementioning

confidence: 99%

Interactions of the Mechanosensitive Channels with Extracellular Matrix, Integrins, and Cytoskeletal Network in Osmosensation

Jiao

Cui

Wang

et al. 2017

Front. Mol. Neurosci.

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Life is maintained in a sea water-like internal environment. The homeostasis of this environment is dependent on osmosensory system translation of hydromineral information into osmotic regulatory machinery at system, tissue and cell levels. In the osmosensation, hydromineral information can be converted into cellular reactions through osmoreceptors, which changes thirst and drinking, secretion of antidiuretic vasopressin (VP), reabsorption of water and salt in the kidneys at systemic level as well as cellular metabolic activity and survival status at tissue level. The key feature of osmosensation is the activation of mechanoreceptors or mechanosensors, particularly transient receptor potential vallinoid (TRPV) and canonical (TRPC) family channels, which increases cytosolic Ca2+ levels, activates osmosensory cells including VP neurons and triggers a series of secondary reactions. TRPV channels are sensitive to both hyperosmotic and hyposmotic stimuli while TRPC channels are more sensitive to hyposmotic challenge in neurons. The activation of TRP channels relies on changes in cell volume, membrane stretch and cytoskeletal reorganization as well as hydration status of extracellular matrix (ECM) and activity of integrins. Different families of TRP channels could be activated differently in response to hyperosmotic and hyposmotic stimuli in different spatiotemporal orders, leading to differential reactions of osmosensory cells. Together, they constitute the osmosensory machinery. The activation of this osmoreceptor complex is also associated with the activity of other osmolarity-regulating organelles, such as water channel protein aquaporins, Na-K-2Cl cotransporters, volume-sensitive anion channels, sodium pump and purinergic receptors in addition to intercellular interactions, typically astrocytic neuronal interactions. In this article, we review our current understandings of the composition of osmoreceptors and the processes of osmosensation.

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Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams with Pup-Deprivation at Different Stages of Lactation

Jin

et al. 2020

Neurochem Res

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Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

Cited by 30 publications

References 147 publications

Approaches Mediating Oxytocin Regulation of the Immune System

Approaches Mediating Oxytocin Regulation of the Immune System

Interactions of the Mechanosensitive Channels with Extracellular Matrix, Integrins, and Cytoskeletal Network in Osmosensation

Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams with Pup-Deprivation at Different Stages of Lactation

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