High-Intensity Focused Ultrasound Ablation of Thyroid Nodules: First Human Feasibility Study

Esnault, Olivier; Franc, Brigitte; Ménégaux, Fabrice; Rouxel, A.; Kerviler, É. de; Bourrier, Pierre; Lacoste, François; Chapelon, Jean‐Yves; Leenhardt, Laurence

doi:10.1089/thy.2011.0141

Cited by 82 publications

(81 citation statements)

References 36 publications

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“…HIFU is currently the least invasive method for the treatment of thyroid nodules, with the most favorable safety profile, posing low risk for infection and other side effects [27]. The study present- Fig.…”

Section: Discussionmentioning

confidence: 90%

“…Thyroglobulin serum levels were measured to evaluate the success of ablation. In clinical diagnosis thyroglobulin constitutes a tumor marker, but it can also be measured to assess thyroid mass or damage to thyroid tissue [27,32]. Thyroglobulin levels increased significantly from baseline to 24 hours and subsequently stabilized at the 3-month follow-up.…”

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confidence: 99%

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Localized Thyroid Tissue Ablation by High Intensity Focused Ultrasound: Volume Reduction, Effects on Thyroid Function and Immune Response

Korkusuz

Sennert

Fehre

et al. 2015

Fortschr Röntgenstr

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Purpose: The aim of this study was to assess the effectiveness of high intensity focused ultrasound (HIFU) in reducing thyroid nodule volume while preserving thyroid function as measured by immunological response. Materials and Methods: 12 patients (9 females) whose average age was 56.9 years (37???81) were treated with HIFU in an ambulatory setting. All patients had a single benign thyroid nodule treated in one HIFU session. The median nodular outline volume (NOV) was 3.4?ml (range 0.6???5.0?ml). The therapeutic ultrasound probe (Echopulse? THC900?888-H) used works with a frequency of 3?MHz, reaching temperatures of 80???90? C and a mean output between 87.6 and 192.8?W. To assess possible effects of HIFU on thyroid function, serum levels of triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), thyroglobulin (hTg) and antibodies against thyroglobulin (TAbs), thyrotropin receptors (TRAbs) and thyroid peroxidase (TPOAbs) were measured at enrollment, 24-hours post-HIFU treatment and at 3-month follow-up.Pre- post thyroglobulin reduction was measured to evaluate the success of ablation and the nodular outline volume (NOV) was evaluated at baseline and the 3-month follow-up to assess effectiveness. Results: All measured hormone levels were within normal ranges and remained stable (p?>?0.05). No clinically meaningful immune reaction was induced (p?>?0.05). Thyroglobulin serum levels increased significantly at 24 hours after ablation (p?

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Section: Discussionmentioning

confidence: 90%

Section: Abb 1 Ein Beispielbild Für Diementioning

confidence: 99%

Localized Thyroid Tissue Ablation by High Intensity Focused Ultrasound: Volume Reduction, Effects on Thyroid Function and Immune Response

Korkusuz

Sennert

Fehre

et al. 2015

Fortschr Röntgenstr

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“…Histological examination revealed that the damage was limited to the treated lesions with a nodule necrosis that ranged from 2 to 80 % [86]. A pilot study of a single hyperfunctioning nodule demonstrated that the nodule developed into a predominantly cystic lesion 2 weeks after treatment and that hyperthyroidism normalized after 3 months was maintained at 18 months [85].…”

Section: Clinical Resultsmentioning

confidence: 98%

Image-guided thermal ablation of benign thyroid nodules

et al. 2016

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Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become symptomatic, surgical excision is still considered standard treatment. In the last few years, several experiences in the treatment of benign thyroid nodules through image-guided percutaneous thermal ablation have been reported with encouraging results, so that currently, these treatments are often proposed as first-choice options for patients with symptomatic benign thyroid nodules. In this paper, we discuss the present literature on the topic, focusing on different techniques available for image-guided percutaneous ablation, particularly radiofrequency (RFA), laser (LA), microwave (MWA), and high-intensity-focus ultrasound (HIFU). Little evidence about the efficacy of MWA and HIFU is now available. According to the literature, good results have been obtained with RFA and LA. Regarding RFA, volume reduction after ablative treatment has been found to range from 47 to 84 % at 3-6 months, and from 62 to 93 % at 1 year; LA also seems to be effective in achieving shrinkage of thyroid nodules, with volume reduction from 37 to 81 % at 3-6 months, and from 13 to 82 % at 1-year follow-up. Moreover, applications of advanced image-guidance modality, such as contrast-enhanced ultrasound and virtual navigation with fusion imaging, are discussed.Keywords Laser Á Radiofrequency Á Microwave Á Highintensity focused ultrasound Á Thyroid nodule SOMMARIO I noduli benigni della tiroide sono una evenienza comune nella popolazione generale. Più spesso vengono scoperti occasionalmente durante un esame ecografico fatto per altri motivi, sono asintomatici e non richiedono alcun trattamento. Qualora i noduli diventino sintomatici, l'escissione chirurgica è ancora considerato il trattamento standard. Tuttavia, negli ultimi anni, è cresciuta l'esperienza circa il trattamento di tali noduli tramite ablazione percutanea sotto guida ecografica tanto che, attualmente, questo viene spesso proposto come trattamento di scelta. Lo scopo del nostro lavoro è fare una revisione della letteratura riguardante l'argomento, con un particolare focus sulle differenti tecniche attualmente a disposizione, in particolare radiofrequenza (RFA), laser (LA), microonde (MWA) e high-intensity-focus ultrasound (HIFU). Al momento ci sono ancora poche evidenze sull'efficacia di MWA e HIFU. Secondo quanto riportato in letteratura, buoni risultati sono stati ottenuti con RFA e LA. Riguardo la radiofrequenza, la riduzione volumetrica dopo la procedura ablativa va da 47 a 84 % a 3-6 mesi e da 62 a 93 % a 1 anno; anche il laser sembra essere efficace nel causare la riduzione del nodulo, con percentuali che vanno da 37 a 81 % a 3-6-mesi a da 13 a 82 % a 1 anno di follow-up Abbiamo poi discusso brevemente le

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“…21,22 In a human feasibility study, Esnault et al demonstrated targeted tissue destruction without any damage to neighboring structures. 23 A favorable outcome has been observed also in patients with primary or secondary hyperparathyroidism. [24][25][26] In this article, we describe the procedure of HIFU for thyroid nodules ablation, as well as the available clinical results, efficacy, complications, and perspectives, based on the current evidence and our own experience.…”

Section: Introductionmentioning

confidence: 97%

High-intensity focused ultrasound for thyroid nodule ablation: the evidence to date

Кovatcheva¹,

Zaletel²

2017

RMI

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Thyroid nodules are common in occurrence and most of them are benign in nature. Some of these nodules are to be treated as they continue to grow or cause undesirable symptoms. Recently, several minimally invasive thermal ablation techniques have been introduced to overcome the complications of traditional methods such as surgery. High-intensity focused ultrasound (HIFU) is the latest advance in treatment modalities, which is a noninvasive procedure that permits localized target destruction without affecting the surrounding tissues. HIFU is currently used in the treatment of various solid malignant and benign tumors. The purpose of this review is to provide an introduction to the literature, principles, and advances of HIFU therapy of benign thyroid nodules, as well as to provide a discussion on its efficacy, complications, and future.

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High-Intensity Focused Ultrasound Ablation of Thyroid Nodules: First Human Feasibility Study

Cited by 82 publications

References 36 publications

Localized Thyroid Tissue Ablation by High Intensity Focused Ultrasound: Volume Reduction, Effects on Thyroid Function and Immune Response

Localized Thyroid Tissue Ablation by High Intensity Focused Ultrasound: Volume Reduction, Effects on Thyroid Function and Immune Response

Image-guided thermal ablation of benign thyroid nodules

High-intensity focused ultrasound for thyroid nodule ablation: the evidence to date

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