Effects of exercise intervention on myocardial function in type 2 diabetes

Hordern, Matthew D.; Coombes, Jeff S.; Cooney, Louise; Jeffriess, Leanne; Prins, Johannes B.; Marwick, Thomas H.

doi:10.1136/hrt.2009.165571

Cited by 74 publications

(58 citation statements)

References 34 publications

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“…Sample size was calculated using data from prior pharmaceutical studies. 11,19 This was based on an anticipated increase in myocardial diastolic tissue velocity of 1.1 cm/s (baseline 5.5Ϯ1.7 cm/s), with 56 patients per group to provide 90% power. Anticipated drop out was accounted for by randomizing 112 patients per group.…”

Section: Discussionmentioning

confidence: 99%

“…There is some suggestion that benefits may be limited to those who participate in moderate to vigorous physical activity. 11 Based on demonstrated improvements in glycemic control and other cardiovascular risk factors, recent guidelines now suggest at least 150 minutes per week of moderate-intensity exercise as a class 1A recommendation for patients with T2DM. 32 Although these goals seem attainable with intensive shortterm lifestyle interventions, the results of this study suggest that implementation of these recommendations into clinical practice over the longer term may prove difficult.…”

Section: Implications For Clinical Managementmentioning

confidence: 99%

“…Patients receiving the intervention were randomized to a 2-stage supervised exercise program 11 that comprised an initial 4-week gym-based exercise program of 2 1-hour exercise sessions per week, supervised by an exercise physiologist, with a further 30 minutes of home-based exercise. Each individualized program sought to provide at least moderate exertion (12 to 13 on the Borg 20-point scale) using a combination of both aerobic and resistance exercise.…”

Section: Exercise Interventionmentioning

confidence: 99%

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Application of an Exercise Intervention on the Evolution of Diastolic Dysfunction in Patients With Diabetes Mellitus

Hare

Hordern

Leano

et al. 2011

Circ: Heart Failure

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Background-Diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes. We studied the impact of an exercise-based lifestyle intervention on the evolution of DD in patients with type 2 diabetes mellitus (T2DM) and prospectively investigated the clinical correlates of DD progression. Methods and Results-A total of 223 outpatients with T2DM were randomized to supervised exercise-based lifestyle intervention (initial gym-based program and lifestyle and diet advice followed by telephone-guided supervision) or usual care. Patients underwent echocardiographic assessment of diastolic function and metabolic and clinical evaluation at baseline and 3 years. Changes in prevalence and evolution of DD were assessed and correlations sought with clinical and metabolic variables. DD was present in 50% of patients at baseline and 54% at 3 years, with no difference between the usual care and intervention groups (60% versus 48%, Pϭ0.10). Abnormal DD at the final visit was independently associated with older age and a decrease in peak oxygen consumption over time (PϽ0.05). There was no impact on glycemic control or exercise capacity. In a subanalysis restricted to patients who finished the full 3-year follow-up, control subjects were independently associated with DD at 3 years (␤ϭ0.90; odds ratio, 2.46; Pϭ0.034), with the only other independent correlate being older age (␤ϭ0.05; odds ratio, 1.06; Pϭ0.019). Conclusions-Despite

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Section: Discussionmentioning

confidence: 99%

Section: Implications For Clinical Managementmentioning

confidence: 99%

Section: Exercise Interventionmentioning

confidence: 99%

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Application of an Exercise Intervention on the Evolution of Diastolic Dysfunction in Patients With Diabetes Mellitus

Hare

Hordern

Leano

et al. 2011

Circ: Heart Failure

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“…Além disso, quanto mais intenso for exercício aeróbio, melhor será o controle glicêmi-co e a sensibilidade à insulina (12,13).…”

Section: Procedimentosunclassified

Efeito do treinamento combinado e aeróbio no controle glicêmico no diabetes tipo 2

et al. 2012

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INTRODUÇÃO: O diabetes tipo 2 é um grupo heterogêneo de doença metabólica causada por uma disfunção na secreção da insulina e/ou ação desta. OBJETIVOS: Comparar o efeito de duas modalidades de treinamento, o combinado (aeróbio e resistido) e o aeróbio, no controle glicêmico no diabetes tipo 2. MATERIAIS E MÉTODOS: A pesquisa caracteriza-se por ser um estudo quase-experimental. Após aprovação do CEP, com registro 09.071.4.08. III, deu-se início ao programa de treinamento combinado e aeróbio. Foram selecionados 24 participantes, de ambos os gêneros, sedentários, com média de idade de 60,41 ± 7,87. Os participantes foram divididos aleatoriamente em dois grupos: treinamento combinado (n = 12) e treinamento aeróbio (n = 12); ambos foram avaliados no início e final do estudo. A concentração sérica de glicose foi determinada pelo sistema Vitros e a hemoglobina glicosilada foi determinada pelo método Cromatografia Líquida de Alta Performance. O treinamento foi realizado três vezes por semana, com duração total de 20 semanas. Os dados são expressos em média e desvio-padrão. Foi aplicado o teste t pareado (p < 0,05) para comparar a média basal e após 20 semanas de treinamento. RESULTADOS: A média da glicose em jejum do treinamento combinado reduziu significativamente, de 167,41 ± 38,13 para 119,83 ± 20,91, sendo que o mesmo ocorreu com o treinamento aeróbio de 189,83 ± 63,57 para 139,91 ± 34,04. Os valores da hemoglobina glicosilada no treinamento combinado e treinamento aeróbio reduziram significativamente, de 8,61 ± 1,17 para 7,25 ± 1,24 e de 9,52 ± 2,46 para 8,37 ± 1,50, respectivamente. CONCLUSÃO: O treinamento combinado foi mais eficaz em relação à hemoglobina glicosilada e o treinamento aeróbio, na glicose plasmática.

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“…Evidence suggests that any reduction in sedentary time is good for metabolic health, 3 and that improvement in metabolic function (as measured by HbA1c) occurs when people with type 2 diabetes increase their levels of moderate activity. 4 However, people with type 2 diabetes find it more difficult to engage in regular physical activity than they do modifying their diet, 5 and most do not regularly undertake activity. 6 It is only recently that interventions designed to ameliorate impaired glucose tolerance (IGT) or improve management of type 2 diabetes have seriously attempted to incorporate physical activity regimens alongside dietary advice or education.…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes and dog walking: patients' longitudinal perspectives about implementing and sustaining physical activity

Peel¹,

Douglas²,

Parry³

et al. 2010

Br J Gen Pract

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Physical activity is particularly important for people with type 2 diabetes, as evidence suggests that any reduction in sedentary time is good for metabolic health. AimTo explore type 2 diabetes patients' talk about implementing and sustaining physical activity. Design of studyLongitudinal, qualitative study using repeat in-depth interviews with 20 patients over 4 years following clinical diagnosis. SettingPatients were recruited from 16 general practices and three hospitals across Lothian, Scotland.

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Effects of exercise intervention on myocardial function in type 2 diabetes

Abstract: ACTRN12607000060448.

Cited by 74 publications

References 34 publications

Application of an Exercise Intervention on the Evolution of Diastolic Dysfunction in Patients With Diabetes Mellitus

Application of an Exercise Intervention on the Evolution of Diastolic Dysfunction in Patients With Diabetes Mellitus

Efeito do treinamento combinado e aeróbio no controle glicêmico no diabetes tipo 2

Type 2 diabetes and dog walking: patients' longitudinal perspectives about implementing and sustaining physical activity

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