Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Jiang

Chemical & Biomedical Imaging

et al. 2023

Intracellular biosynthetic nanomaterials offer tremendous opportunities for chemical biomedical imaging. A wide range of biologically active tissues are available for biosynthesis, including cells, bacteria, plants, and viruses. Nanomaterials synthesized by intracellular biomineralization with outstanding biosafety and optical properties attract unique attention. Herein, an overview of biosynthetic tunable nanomaterials within active biological tissues for chemical biomedical imaging is presented. The synthetic mechanisms and nanostructures of biosynthetic nanomaterials are summarized from the perspective of different active organisms. The ability of biosynthesis is commonly used for green synthesis of metal nanoparticles compared to those synthesized by physical or chemical methods. The tunable characteristics of these nanoparticles make it possible to utilize them as fluorescence imaging, surface-enhanced Raman spectral mapping, nuclear magnetic resonance imaging, and other biomedical photonics tools. Importantly, current issues, insights, and future tendencies of development are presented based on current biosynthetic optical nanomaterials for chemical biomedical imaging. This paper provides the summary of biosynthetic optical nanomaterials and a critical assessment of potential biomedical imaging applications in this emerging field, laying the foundation for future studies.

Section: Chemical Biomedical Imagingmentioning

confidence: 99%

Tunable Nanomaterials of Intracellular Crystallization for In Situ Biolabeling and Biomedical Imaging

Jiang

Chemical & Biomedical Imaging

et al. 2023

Macromolecular Symposia

“…However, from the all known materials which show anticancer activity, magnetic nanoparticles are introduced as an excellent candidate for the biological imaging or separation. [30,31] Magnetic nanoparticles have been utilized for drug and gene targeting, [32] separation of proteins, DNA and cells from samples, [33,34] as magnetic biosensors, [35] in cancer therapy as heat mediator. [36] Fe 3 O 4 possesses large surface area with reactive surface, it is easily separable by magnetic field, both magnetically and chemically stable and owes very less toxicity.…”

Section: Introductionmentioning

confidence: 99%

Study of Anticancer Properties of Graphene Oxide–Metal Oxide Composite

Dabhi,

Gahlot,

Mirza

et al. 2024

Graphene and graphene oxide (GO) have garnered significant attention due to their exceptional properties. GO, enriched with various functional groups such as epoxy, hydroxyl, and carboxylic groups, has exhibited remarkable potential in biomedical applications. The combination of GO with metals has proven to be a promising platform for cellular imaging, with this study focusing on the preparation of diverse hybrids of GO with metal oxides (GO/MO) and their potential as anticancer agents. In this research, GO is functionalized with MOs like TiO2, Fe3O4, and Cu2O using specific chemical methods and investigated for the anticancer activity for the application as cancer therapeutic agent. The resulting GO/MO hybrids exhibits favorable thermal and mechanical properties. Moreover, their cytotoxicity against human lung cancer cells is assessed in vitro, revealing the promising anticancer activity of GO/MO hybrids. Notably, the GO/Cu2O hybrid demonstrates particularly high cytotoxicity in human lung cancer cells.

“…Moreover, magnetic nanoparticles with high M s have also been used in targeted drug delivery and hyperthermia for their easy manipulation via magnetic eld (Vangijzegem et al 2019). Similarly, in bio-sensor and bio-separation, high magnetic moments were required to shift the functionalized labels to the speci c sensor sites and get high separation yield by magnet (Zimina et al 2022;Chen et al 2020). Due to their high M s , low coercivity (H c ), high permeability and Curie temperature, FeCo nanoparticles have been carried out extensive research (Kolhatkar et al 2013;Desautels et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The influence of reaction temperature and surfactant on the magnetic and catalytic properties of FeCo nanoparticles

Liao

Wei

Xin

et al. 2023

Preprint

FeCo nanoparticles were prepared by controlling the reaction temperature and addition of surfactant. With the increasing of reaction temperature, CoFe2O4 impurities disappeared and crystalline FeCo nanoparticles were got. High Ms of 218.5 emu/g and low Hc of 90.2 Oe were observed after reacting at 150 oC. The best OER (oxygen evolution reaction) properties with low onset potential (0.73 V) and small Tafel value (105 mV/dec) were found in FeCo nanoparticles prepared at 150 oC. With increasing the surfactant ratio, the purity of FeCo particles did not change. However, the repulsive forces between the polar ends of oleic acid molecules induced the formation of uniform small FeCo nanoparticles. Large Ms of 166.4 emu/g and small Hc of 75.0 Oe were observed when the surfactant ratio was 3:1. The best OER activity with low onset potential (0.63 V) and small Tafel value (67 mV/dec) were found in FeCo nanoparticles prepared with the surfactant ratio of 3:1. The improved OER activity was contributed to the impurity reduction, the better crystallization, the larger surface area and the better magnetic properties, which could provide small electric resistance, more active sites and easy electron transfer.