An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in
            <i>Caenorhabditis elegans</i>

Takeuchi, Masaru; Kawakami, Minoru; Ishihara, Takeshi; Amano, Tsuyoshi; Kondo, Kazunori; Izui, Katsura

doi:10.1073/pnas.95.20.11775

Cited by 65 publications

(75 citation statements)

References 43 publications

(34 reference statements)

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“…Expression of osm-7: For genes known to affect the defecation rhythm, expression is required in the intestine (Take-Uchi et al 1998;Dal Santo et al 1999). In contrast, the only previously studied Osr gene (osr-1) is required in the hypodermis for its function (Solomon et al 2004).…”

Section: Genetic Interaction Of Osr Mutantsmentioning

confidence: 99%

Identification of a Novel Gene Family Involved in Osmotic Stress Response inCaenorhabditis elegans

2006

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Organisms exposed to the damaging effects of high osmolarity accumulate solutes to increase cytoplasmic osmolarity. Yeast accumulates glycerol in response to osmotic stress, activated primarily by MAP kinase Hog1 signaling. A pathway regulated by protein kinase C (PKC1) also responds to changes in osmolarity and cell wall integrity. C. elegans accumulates glycerol when exposed to high osmolarity, but the molecular pathways responsible for this are not well understood. We report the identification of two genes, osm-7 and osm-11, which are related members of a novel gene family. Mutations in either gene lead to high internal levels of glycerol and cause an osmotic resistance phenotype (Osr). These mutants also have an altered defecation rhythm (Dec). Mutations in cuticle collagen genes dpy-2, dpy-7, and dpy-10 cause a similar Osr Dec phenotype. osm-7 is expressed in the hypodermis and may be secreted. We hypothesize that osm-7 and osm-11 interact with the cuticle, and disruption of the cuticle causes activation of signaling pathways that increase glycerol production. The phenotypes of osm-7 are not suppressed by mutations in MAP kinase or PKC pathways, suggesting that C. elegans uses signaling pathways different from yeast to mount a response to osmotic stress.

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Section: Genetic Interaction Of Osr Mutantsmentioning

confidence: 99%

Identification of a Novel Gene Family Involved in Osmotic Stress Response inCaenorhabditis elegans

2006

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“…Other DEG/ENaC channels in bilaterians are the degenerins, mechanosensitive ion channels from C. elegans (O'Hagan et al, 2005;Árnadóttir and Chalfie, 2010), the FLR-like channels from C. elegans (Take-uchi et al, 1998), and ripped pocket (RPK) and pickpockets (PPKs) from Drosophila (Zelle et al, 2013) (Fig. 10).…”

Section: Trichoplax Adhaerensmentioning

confidence: 99%

Peptide-gated ion channels and the simple nervous system of Hydra

Gründer

Assmann

2015

Journal of Experimental Biology

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Neurons either use electrical or chemical synapses to communicate with each other. Transmitters at chemical synapses are either small molecules or neuropeptides. After binding to their receptors, transmitters elicit postsynaptic potentials, which can either be fast and transient or slow and longer lasting, depending on the type of receptor. Fast transient potentials are mediated by ionotropic receptors and slow long-lasting potentials by metabotropic receptors. Transmitters and receptors are well studied for animals with a complex nervous system such as vertebrates and insects, but much less is known for animals with a simple nervous system like Cnidaria. As cnidarians arose early in animal evolution, nervous systems might have first evolved within this group and the study of neurotransmission in cnidarians might reveal an ancient mechanism of neuronal communication. The simple nervous system of the cnidarian Hydra extensively uses neuropeptides and, recently, we cloned and functionally characterized an ion channel that is directly activated by neuropeptides of the Hydra nervous system. These results demonstrate the existence of peptide-gated ion channels in Hydra, suggesting they mediate fast transmission in its nervous system. As related channels are also present in the genomes of the cnidarian Nematostella, of placozoans and of ctenophores, it should be considered that the early nervous systems of cnidarians and ctenophores have co-opted neuropeptides for fast transmission at chemical synapses.

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“…Although the screen for single mutants with a strong Daf-c phenotype at 25°C is near saturation (Malone and Thomas, 1994), many syn-Daf mutants remain to be isolated (Avery, 1993;Katsura et al, 1994;Iwasaki et al, 1997;Take-Uchi et al, 1998;Ailion et al, 1999;Sym et al, 2000;Daniels et al, 2000;Ailion and Thomas, 2000;Lanjuin and Sengupta, 2002). To identify new genes that regulate dauer formation, we isolated 44 mutants showing Daf-c phenotypes in the unc-31(e169) mutant background and named them sdf (synthetic dauer formation abnormal; N.S., T.I.…”

Section: Sdf-9 Regulates Dauer Formationmentioning

confidence: 99%

“…In addition, there are many other genes that, when mutated, result in only low-penetrance Daf-c, synthetic Daf-c (syn-Daf) and/or Hid (high temperatureinduced dauer formation) phenotypes. Syn-Daf mutants and Hid mutants form dauer larvae only in a certain mutant background and at 27°C (a temperature too high for the reproduction of C. elegans), respectively (Bargmann et al, 1990;Avery, 1993;Katsura et al, 1994;Iwasaki et al, 1997;Prasad et al, 1998;Take-Uchi et al, 1998;Ailion et al, 1999;Sze et al, 2000;Sym et al, 2000;Daniels et al, 2000;Ailion and Thomas, 2000;Lanjuin and Sengupta, 2002). The presence of such genes suggests that the daf pathways may be bifurcated further or modified by other pathways.…”

Section: Introductionmentioning

confidence: 99%

SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling inC. elegans

Suzuki²,

et al. 2003

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The dauer larva of the nematode Caenorhabditis elegans is a good model system for investigating the regulation of developmental fates by environmental cues. Here we show that SDF-9, a protein tyrosine phosphatase-like molecule, is involved in the regulation of dauer larva formation. The dauer larva of sdf-9 mutants is different from a normal dauer larva but resembles the dauer-like larva of daf-9 and daf-12 dauer-constitutive mutants. Like these mutants, the dauer-constitutive phenotypes of sdf-9 mutants were greatly enhanced by cholesterol deprivation. Epistasis analyses, together with the relationship between sdf-9 mutations and daf-9 expression, suggested that SDF-9 increases the activity of DAF-9 or helps the execution of the DAF-9 function. SDF-9 was expressed in two head cells in which DAF-9 is expressed. By their position and by genetic mosaic experiments, we identified these cells as XXXL/R cells, which are known as embryonic hypodermal cells and whose function at later stages is unknown. Killing of the sdf-9-expressing cells in the wild-type first-stage larva induced formation of the dauer-like larva. Since this study on SDF-9 and former studies on DAF-9 showed that the functions of these proteins are related to those of steroids, XXXL/R cells seem to play a key role in the metabolism or function of a steroid hormone(s)that acts in dauer regulation.

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An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans

Cited by 65 publications

References 43 publications

Identification of a Novel Gene Family Involved in Osmotic Stress Response inCaenorhabditis elegans

Identification of a Novel Gene Family Involved in Osmotic Stress Response inCaenorhabditis elegans

Peptide-gated ion channels and the simple nervous system of Hydra

SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling inC. elegans

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