Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance

Melnik, Bodo C.; John, Swen Malte; Plewig, Gerd

doi:10.2340/00015555-1677

Cited by 80 publications

(78 citation statements)

References 67 publications

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“…In the past, nutrition was not a proven cause of acne. However, recent publications show a link between some dietary factors and acne . Nowadays, main food classes considered triggering acne are dairy products (especially skim milk) and hyperglycaemic carbohydrates …”

Section: Resultsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

105

106

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Background Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.ResultsAcne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.ConclusionExposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

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Section: Resultsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

105

106

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“…2 Hyperglycaemic carbohydrates and insulinotrophic milk/dairy products have been identified to drive acne pathogenesis by promoting increased insulin/ insulin like growth factor-1 signalling. 9 A study by Tasli et al has suggested that insulin like growth factor-1 cytosine-adenine repeat (IGF-1 CA 19) polymorphism may contribute to a predisposition to acne in Turkish patients. 1 A study by Balta et al suggested that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of insulin resistance in acne vulgaris

et al. 2017

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INTRODUCTIONAcne is common skin problem among adolescents and young adults. The lesions can range from comedones to nodules and cysts leaving behind scars. It has a significant psychological impact on the patients. Acne is influenced by factors like diet, lifestyle and hormones. Recently the role of insulin resistance in acne is being widely researched.Acne vulgaris is a multifactorial disease of the skin. Even though acne is considered an androgen-dependent disease, occurrence of acne doesn't correlate with plasma androgen levels. Increased serum levels of insulin like growth factor (IGF-1) have been observed in adult women and men with acne, giving rise to the possibility of the role of growth hormone (GH), hyperinsulinemia, and IGF1 in acne. A positive correlation between the mean facial sebum excretion rate and serum IGF-1 levels has been demonstrated in post-adolescent acne patients. 2Some studies have discussed about the correlation between insulin resistance and severity of acne. This was attributed to increased blood glucose which in turn stimulates increased insulin secretion. Increased insulin decreases availability of binding protein for IGF-1 which facilitates the effects of IGF-1 on basal keratinocyte proliferation. Also insulin stimulates synthesis of androgens which can cause acne. In India, prevalence data from a dermatology clinic in a teaching hospital in Varanasi reported acne in 50.6% of boys and 38.13% of girls in the age group of 12-17 years. There are believed to be no gender differences in acne prevalence, although such difference are often reported and, very likely represent social biases. In clinics in the ABSTRACT Background: Acne is common skin problem among adolescents and young adults. Recently the role of insulin resistance in acne is being widely researched. The objectives of the study were to evaluate insulin resistance in acne, to compare the insulin resistance among cases and controls using homeostasis model assessment of insulin resistance Methods: 45 cases and 45 controls were recruited. Acne severity was graded using the global acne grading system (GAGS). Fasting glucose, fasting insulin levels were done and insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR). Results: We did not find any statistically significant difference in fasting insulin levels between cases and controls. However, a weak positive correlation between acne severity and fasting insulin levels (r =0.3, p=0.04) were observed. Fasting glucose levels and HOMA-IR values observed between cases and controls were not statistically significant (p=0.05, p=0.59 respectively). Conclusions: Our study did not suggest a major role of insulin resistance in acne.

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“…Patients with acne often exhibit increased levels of serum glucose and insulin as well as insulin resistance, and its association has been long recognized [72]. Interestingly, in patients with acne vulgaris, desnutrin, also called adipose triglyceride lipase (ATGL), has been found to be low and to have a positive correlation with insulin and HOMA-IR values [73].…”

Section: Introductionmentioning

confidence: 99%

Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

González-Saldivar

Rodríguez-Gutiérrez

Ocampo‐Candiani

et al. 2016

Dermatol Ther (Heidelb)

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Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40–50% of the global population is labeled at “high risk” (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted. In both diabetes and obesity, genetic, epigenetic, and environmental factors overlap and are inclusive rather than exclusive. De facto, 70–80% of the patients with obesity and virtually every patient with type 2 diabetes have insulin resistance. Insulin resistance is a well-known pathophysiologic factor in the development of type 2 diabetes, characteristically appearing years before its diagnosis. The gold standard for insulin resistance diagnosis (the euglycemic insulin clamp) is a complex, invasive, costly, and hence unfeasible test to implement in clinical practice. Likewise, laboratory measures and derived indexes [e.g., homeostasis model assessment of insulin resistance (HOMA-IR-)] are indirect, imprecise, and not highly accurate and reproducible tests. However, skin manifestations of insulin resistance (e.g., acrochordons, acanthosis nigricans, androgenetic alopecia, acne, hirsutism) offer a reliable, straightforward, and real-time way to detect insulin resistance. The objective of this review is to aid clinicians in recognizing skin manifestations of insulin resistance. Diagnosing these skin manifestations accurately may cascade positively in the patient’s health by triggering an adequate metabolic evaluation, a timely treatment or referral with the ultimate objective of decreasing diabetes and obesity burden, and improving the health and the quality of care for these patients.

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Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance

Cited by 80 publications

References 67 publications

The influence of exposome on acne

The influence of exposome on acne

A comparative study of insulin resistance in acne vulgaris

Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

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