Amarkand: A comprehensive review on its ethnopharmacology, nutritional aspects and taxonomy

Narkhede, Aarti; Kasote, Deepak M.; Kuvalekar, Aniket; Harsulkar, Abhay; Jagtap, Suresh

doi:10.5455/jice.20160324054420

Cited by 14 publications

(10 citation statements)

References 18 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Orchids belong to the plant family Orchidaceae, one of the most diverse group among the angiosperm with near 25,000 species ( Behera et al, 2013 ). Aside from their ornamental value, orchids are also acknowledged for their use in traditional medicines ( Bulpitt, 2005 ; Behera et al, 2013 ; Pant, 2013 ; Patil and Mahajan, 2013 ; Narkhede et al, 2016 ). Chinese medicine was probably the first to describe orchids for their medicinal use.…”

Section: Introductionmentioning

confidence: 99%

Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′-Hydroxybenzyl)-4,8-Dimethoxyphenanthrene-2,7-Diol

et al. 2018

View full text Add to dashboard Cite

Background: Ethnopharmacological studies demonstrated the potential for Eulophia species to treat inflammation, cancer, and cardio-metabolic diseases. The aim of the study was to investigate the vasorelaxant effect of ethanolic Eulophia macrobulbon (EM) extract and its main phenanthrene on rat isolated mesenteric artery and to investigate the hypotensive effect of EM.Methods: The vasorelaxant effects of EM extract or phenanthrene and the underlying mechanisms were evaluated on second-order mesenteric arteries from Sprague Dawley rats. In addition, the acute hypotensive effect was evaluated in anesthetized rats infused with cumulative concentrations of the EM extract.Results: Both EM extract (10-4–1 mg/ml) and phenanthrene (10-7–10-4 M) relaxed endothelium-intact arteries, an effect that was partly reduced by endothelium removal (p < 0.001). A significant decrease in the relaxant effect of the extract and the phenanthrene was observed with L-NAME and apamin/charybdotoxin in endothelium-intact vessels, and with iberiotoxin in denuded vessels. SNP (sodium nitroprusside)-induced relaxation was significantly enhanced by EM extract and phenanthrene. By contrast, ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one), 4-aminopyridine and glibenclamide (endothelium-denuded vessels) and indomethacin (endothelium-intact vessels) had no effect. In calcium-free solution, both the EM extract and phenanthrene inhibited extracellular Ca2+-induced contraction in high KCl and phenylephrine (PE) pre-contracted rings. They also inhibited the intracellular Ca2+ release sensitive to PE. The acute infusion of EM extract (20 and 70 mg/kg) induced an immediate and transient dose-dependent hypotensive effect.Conclusion: The ethanolic extract of EM tubers and its main active compound, 1-(4′-hydroxybenzyl)-4,8-dimethoxyphenanthrene-2,7-diol (phenanthrene) induced vasorelaxant effects on rat resistance vessels, through pleiotropic effects including endothelium-dependent effects (NOS activation, enhanced EDH production) and endothelium-independent effects (opening of KCa channels, inhibition of Ca2+ channels, inhibition of intracellular Ca2+ release and PDE inhibition).

show abstract

Section: Introductionmentioning

confidence: 99%

Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′-Hydroxybenzyl)-4,8-Dimethoxyphenanthrene-2,7-Diol

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Orchids are commonly used in traditional medicine in Asia, Europe and America. Their pharmacological activities include the treatment of pulmonary, autoimmune and inflammatory diseases, cancer, and diabetes (Narkhede et al, 2016). The ethanolic extract of E. m ac r o b u l b o n c on ta i ns fl a vo no i d s , t er p e no i d s an d phosphodiesterase type 5 (PDE5) inhibitor, so it could be a pulmonary vasodilator (Temkitthawon et al, 2017).…”

Section: Crataegus Rhipidophylla Gandmentioning

confidence: 99%

Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension

et al. 2020

View full text Add to dashboard Cite

Background: Pulmonary hypertension (PH) is a progressive disease that is associated with pulmonary arteries remodeling, right ventricle hypertrophy, right ventricular failure and finally death. The present study aims to review the medicinal plants and phytochemicals used for PH treatment in the period of 1994-2019. Methods: PubMed, Cochrane and Scopus were searched based on pulmonary hypertension, plant and phytochemical keywords from August 23, 2019. All articles that matched the study based on title and abstract were collected, non-English, repetitive and review studies were excluded. Results: Finally 41 studies remained from a total of 1290. The results show that many chemical treatments considered to this disease are ineffective in the long period because they have a controlling role, not a therapeutic one. On the other hand, plants and phytochemicals could be more effective due to their action on many mechanisms that cause the progression of PH. Conclusion: Studies have shown that herbs and phytochemicals used to treat PH do their effects from six mechanisms. These mechanisms include antiproliferative, antioxidant, antivascular remodeling, anti-inflammatory, vasodilatory and apoptosis inducing actions. According to the present study, many of these medicinal plants and phytochemicals can have effects that are more therapeutic than chemical drugs if used appropriately.

show abstract

“…An example of one of the groups of medicinal plants, credited with innumerable medicinal qualities used since ancient times is Amarkand [8] . Tribal people have extensively used members of genus Eulophia and Dioscorea bulbifera L. as an important constituent in their diet and called them Amarkand.…”

Section: Research Papermentioning

confidence: 99%

Validation of the Immunomodultory Potential of Amarkand Species

Narkhede¹,

Nirmal²,

Nagarkar³

et al. 2017

pharmaceutical-sciences

View full text Add to dashboard Cite

Narkhede, et al: Immunomodulatory Potential of AmarkandAmarkand plants are routinely used by Indian tribes for health and longevity. Taxonomically, Amarkand includes species from genera Eulophia and Dioscorea. Comparative immunomodulatory potential of Amarkand extracts were examined through biochemical, hematological, serological and histopathological analysis. A significant effect on the modulation of immune reactivity was observed in bulbils of Dioscorea bulbifera and tubers of Eulophia ochreata. A significant increase was also observed in relative organ weights, hematological parameters and total protein by E. ochreata (500 mg/kg) treatment compared to the negative control group. While aminotransferase enzyme levels have shown a significant decrease by the treatment of E. ochreata and D. bulbifera extracts, D. bulbifera (300 mg/kg) showed greater (61.7±3.62 %) neutrophil adhesion and a significant increase in delayed type hypersensitivity response. E. ochreata treatment showed increased haemagglutination titre compared to negative control, thereby providing evidence that D. bulbifera and E. ochreata possessed immunomodulatory activity. Histopathology of rat organs treated with D. bulbifera and E. ochreata, showed normal cytoarchitecture and less neutrophil infiltration as compared to the negative control group, suggesting no evidence of pathological signs. Our findings demonstrated that E. ochreata and D. bulbifera have immunomodulatory potential and provide the basis for an alternative approach to investigate new traditional remedies.

show abstract

Amarkand: A comprehensive review on its ethnopharmacology, nutritional aspects and taxonomy

Cited by 14 publications

References 18 publications

Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′-Hydroxybenzyl)-4,8-Dimethoxyphenanthrene-2,7-Diol

Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′-Hydroxybenzyl)-4,8-Dimethoxyphenanthrene-2,7-Diol

Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension

Validation of the Immunomodultory Potential of Amarkand Species

Contact Info

Product

Resources

About