Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Islam, Muhammad Torequl; Quispe, Cristina; Herrera‐Bravo, Jesús; Sarkar, Chandan Kumar; Sharma, Rohit; Garg, Neha; Fredes, Larry Ibarra; Martorell, Miquel; Alshehri, Mohammed M.; Sharifi‐Rad, Javad; Daştan, Sevgi Durna; Călina, Daniela; Alsafi, Radi; Alghamdi, Saad; Batiha, Gaber El‐Saber; Cruz‐Martins, Natália

doi:10.1155/2021/4224816

Cited by 19 publications

(5 citation statements)

References 213 publications

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“…In humans that suffer the infection for the first time, DENV causes asymptomatic to mild dengue fever disease. Subsequent DENV infections can cause more severe diseases, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which can be fatal if not treated [ 71 , 72 ].…”

Section: Viral Infections In Nsg and Nrg Humanized Mouse Modelsmentioning

confidence: 99%

Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

Kitsera

Brunetti

Rodríguez

2023

Viruses

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Humanized mouse models have been widely used in virology, immunology, and oncology in the last decade. With advances in the generation of knockout mouse strains, it is now possible to generate animals in which human immune cells or human tissue can be engrafted. These models have been used for the study of human infectious diseases, cancers, and autoimmune diseases. In recent years, there has been an increase in the use of humanized mice to model human-specific viral infections. A human immune system in these models is crucial to understand the pathogenesis observed in human patients, which allows for better treatment design and vaccine development. Recent advances in our knowledge about viral pathogenicity and immune response using NSG and NRG mice are reviewed in this paper.

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Section: Viral Infections In Nsg and Nrg Humanized Mouse Modelsmentioning

confidence: 99%

Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

Kitsera

Brunetti

Rodríguez

2023

Viruses

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“…Renin-angiotensin system (RAS) is highly affected in Covid-19 owing to the down-regulation of ACE2 and interconnected with the progress of ALI, ARDS, and injury in multiple organs [ 47 ]. It has been reported recently that DIP reduces RAS and circulating AngII serum levels through an AD-dependent pathway [ 46 , 47 ] or PDE inhibition pathway [ 48 , 49 ]. Furthermore, DIP also mitigates Covid-19-induced complications like acute kidney injury [ 50 ], acute coronary syndrome [ 51 ], acute brain injury [ 52 ], and cytokine storm-mediated multi-organ injury [ 53 , 54 ].…”

Section: Adenosinergic Pathway and Dip In Covid-19mentioning

confidence: 99%

Dipyridamole and adenosinergic pathway in Covid-19: a juice or holy grail

Al-Kuraishy

Al-Gareeb

Elekhnawy

et al. 2022

Egypt J Med Hum Genet

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Background Coronavirus disease 2019 (Covid-19) is an infectious worldwide pandemic triggered by severe acute respiratory coronavirus 2 (SARS-CoV-2). This pandemic disease can lead to pro-inflammatory activation with associated acute lung injury and acute respiratory distress syndrome. Main body of the abstract SARS-CoV-2 infection is linked with inhibition of adenosine and activation of phosphodiesterase. Dipyridamole (DIP) is a nucleoside transport and phosphodiesterase inhibitor so that it may potentially affect SARS-CoV-2 infection and its accompanying inflammations. Therefore, the primary objective of this mini-review study was to elucidate the potential beneficial impacts of DIP on the adenosinergic pathway in Covid-19. A systemic search was done using online databases with relevant keywords. The findings of the present study illustrated that DIP directly or indirectly, through augmentation of adenosine and inhibition of phosphodiesterase, mitigates Covid-19 outcomes. Conclusion Our study concluded that DIP has a potential therapeutic effect in the management and treatment of Covid-19. This could be attained either directly, through anti-SARS-CoV-2, anti-inflammatory, and anti-platelets properties, or indirectly, through augmentation of extracellular adenosine, which has anti-inflammatory and immune-regulatory effects. However, extensive randomized clinical trials, and clinical and prospective research in this area are required to demonstrate the safety and therapeutic efficacy of DIP and adenosine modulators in the treatment of Covid-19.

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“…Dengue fever is caused by the dengue virus, which is transmitted to humans primarily through the bites of infected female mosquitoes, mainly the Aedes aegypti mosquito [2].The dengue virus does not develop at the base of the mosquito's proboscis [3]. Instead, the virus replicates and multiplies in the mosquito's midgut after it feeds on the blood of an infected person [4]. The virus then moves to the salivary glands of the mosquito, from where it can be transmitted to another person during a subsequent mosquito bite [5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the spread of dengue hemorrhagic fever with the moran index (Case study of Sukoharjo Regency in 2019)

Puspita,

Hadibasyir,

Renika

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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One of the endemic diseases that can be found in tropical areas is DHF or Dengue Hemorrhagic Fever (DHF). Dengue fever can be transmitted through Aedes aegypti mosquitoes that have been infected with the dengue virus. It is estimated that the level of dependence on DHF is always related to the infected area around it. DHF can spread to other people through mosquito bites. Sukoharjo Regency in 2018 recorded 35 cases of DHF sufferers and zero patients died. Increased up to 90% in 2019, there were 317 cases of dengue fever and 10 patients died. Therefore, the purpose of this study is to determine the autocorrelation of the spread of DHF in Sukoharjo Regency in 2019. This study used data on the number of DHF sufferers per subdistrict in Sukoharjo Regency in 2019. The research method used the calculation of the Moran Index. Calculation of Moran’s Index produced a value I = -0.181. Moran’s index value is in the range - 1≤I< 0 so that it indicates a negative autocorrelation. The correlation is classified to be a weak relationship. Negative spatial autocorrelation values indicate locations that are close to each other have values that are not close together. Subdistricts with a high number of sufferers tended to be irregular.

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Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Cited by 19 publications

References 213 publications

Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

Dipyridamole and adenosinergic pathway in Covid-19: a juice or holy grail

Analysis of the spread of dengue hemorrhagic fever with the moran index (Case study of Sukoharjo Regency in 2019)

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